2
Why does the liver enlarge in thalassemia?
- 1 people answered
3 Votes
1 Contributor
3381 Views 
0 Saved
3 Votes 1 Contributor3381 Views 0 SavedYou might also be interested in
My amylase are increasing day by day. please need your cooperation. How can you help me. I came from Bangladesh.
Gluconeogenesis is a metabolic process that results in the generation of glucose from non-carbohydrate carbon substrates like lactate, glycerol, and glycogenic amino acids. Liver cells or hepatocytes have glucagon receptors. Glucagon can easily target the liver. When glucagon binds to the glucagon r....
Sir do ur hospital do treatment for liver jondis
Akanksha Pardeshi
The enlargement of Liver happens due to continuous transfusions without adequate chelation.
If there is no chelation at all it will enlarge quickly and vice versa. So, Hepatomegaly does happen in Thalassemia because Liver stores the excess iron which remains in the body due to inadequate chelation. Is the case of thalassemia, organs are expanding due to the dual effects of low hemoglobin in the body. In some cases, the bone marrow can produce some amount of misshaped RBCs.
The Spleen then becomes hyperactive to get rid of these cells, which in turn leads to the bone marrow trying to work some more - in effect, a vicious cycle develops where the spleen will get enlarged and the bone marrow will expand, weakening the bones. The only key to Success over Thalassemia is Adequate Transfusion with Adequate Chelation without worrying about future.